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The Brain Collection Contents

Below you will find key facts about the collection

Fact Sheet

  • A total of 9,479 brains – some are missing due to various circumstances.

    • The collection contains approximately 50,000 tissue blocks embedded in paraffin (FFPE blocks), i.e. all the blocks originally made for diagnostics.

    • Histological slide trays from approximately 6500 patients are preserved, i.e. approximately 250,000 slides.

  • The brains are collected from Danish psychiatric patients between 1945-1982. The most frequent diagnoses among the patients are dementia, schizophrenia, mania, and depression.

  • All brains have been autopsied and sectioned accordingly; consequently, there are no whole brains in the collection. The tissue is stored as sections.

  • All tissue is either preserved in formalin or embedded in paraffin.

  • There are no brains from people without disease (control brains).

  • There are no fresh frozen tissue.

  • There is no service for ordering tissue for shipping – all projects are collaborations where scientists visit the brain collection and dissect relevant areas of the brains for their project.

  • Patient data such as age, date of death, and clinical diagnoses are available for each brain. 

  • All information regarding the patients and tissue is written on paper in Danish and often in handwriting. This includes the medical records, pathology reports, responsum/summary and the associated protocol books.

  • The medical records are mainly stored in the Danish National Archive with limited accessibility.

Distribution of Diagnoses

 

OBS: Based on preliminary numbers.

Age Distribution of Patients

The majority of the examined patients died old — some after living a long life at a psychiatric hospital.

This plot was calculated to give an impression of the age of potential next of kin alive today.

Available Brain Regions for FFPE Blocks

Number of brains by region
Region Number of Brains
Amygdala 268
Centrum semiovale 71
Central region 318
Cerebellum 3340
Chiasma opticum 57
Corpus callosum 5
Corpus geniculatum laterale 1
Corpus pineale 21
Corpus striatum 9132
Cortex calcarinus 32
Cuneus 16
Gyrus cinguli 17
Gyrus frontalis inferior 15
Gyrus frontalis medius 29
Gyrus frontalis superior 322
Gyrus orbitalis 47
Gyrus rectus 11
Gyrus temporalis inferior 18
Gyrus temporalis medius 24
Gyrus temporalis superior 29
Hippocampus 9200
Hypothalamus 482
Insula 123
Lobulus parietalis inferior 1
Lobulus parietalis superior 11
Lobus frontalis 40
Lobus occipitalis 33
Lobus parietalis 33
Lobus temporalis 28
Medulla oblongata 47
Mesencephalon 6915
Metathalamus 1
Nucleus caudatus 42
Nucleus dentatus 28
Nucleus lentiformis 25
Operculum parietale 2
Operculum temporale 14
Pituitary gland 5
Plexus choroideus 12
Polus frontalis 6096
Polus occipitalis 1123
Polus temporalis 1177
Pons 2242
Putamen 57
Subthalamus 19
Thalamus 329
Vermis cerebelli 17

 

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